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Linea de Investigacion:

MECANISMOS DE RENOVACIÓN CELULAR ADENOHIPOFISARIA

Investigador Superior CONICET:
Dra. Adriana Seilicovich

Integrantes:
Dra. Gabriela Jaita (Investigadora Asistente CONICET) gjaita@fmed.uba.ar
Dra. Sandra Zárate (Investigadora Asistente CONICET) szarate@fmed.uba.ar
Lic. en Biotecnología María Florencia Gottardo(Becaria doctoral CONICET) florenciagottardo@gmail.com
Florencia Lucía Merino (estudiante) flor.merino@live.com.ar

CONTACTO
Email: adyseili@fmed.uba.ar
Telefono: 5411-5950-9500 ext 2156

Direccion: Instituto de Investigaciones Biomedicas (UBA-CONICET), Facultad de Medicina, Universidad de Buenos Aires.
Paraguay 2155, piso 10, Buenos Aires, Argentina

 

Area de Interés:
Estudio de los mecanismos involucrados en la acción de los esteroides gonadales en la renovación celular adenohipofisaria.

Research Interest:
Mechanisms involved in the action of gonadal steroids in anterior pituitary cell renewal.

Publicaciones en los 5 últimos años:

Estrogens upregulates c-FLIPlong expression in
anterior pituitary cells.
Jaita G, Zárate S, Ferraris J, Gottardo M F, Eijo G, Magri M L,
Pisera D, Seilicovich A. (En revisión Horm Metab Res, agosto 2015)

Opposite effects of dihydrotestosterone and estradiol on apoptosis in the anterior pituitary gland from male rats.
Magri ML, Gottardo MF, Zárate S, Eijo G, Ferraris J, Jaita G,
Moreno Ayala M, Candolfi M, Pisera D, Seilicovich A. Endocrine doi: 10.1007/s12020-015-0719-2

Lack of oestrogenic inhibition of the NF-?B pathway in pituitary tumour cells.
Eijo G, Gottardo MF, Jaita G, Magri ML, Moreno Ayala M, Zárate S, Candolfi M, Pisera D, Seilicovich A. J Neuroendocrinol
2015;27(9):692-701. doi: 10.1111/jne.12296.

Antiapoptotic factor Humanin is expressed in normal and tumoral pituitary cells and protects them from TNF-a-induced apoptosis
Gottardo MF, Jaita G, Magri ML, Zárate S, Moreno Ayala M, Ferraris
J, Eijo G, Pisera D, Candolfi M, Seilicovich A.. PlosOne 2014 9(10):e111548.

Prolactin induces apoptosis of lactotropes in female rodents.
Ferraris J, Zárate S, Jaita G, Boutillon F, Bernadet M, Auffret J,
Seilicovich A, Binart N, Goffin V, Pisera D. PlosOne 2014;9(5):e97383.

Estrogens induce expression of membrane-associated estrogen
receptor a isoforms in lactotropes.
Zarate S, Jaita G, Ferraris J, E Eijo G, Magri ML, Pisera D,
Seilicovich A. PlosOne 2012;7(7):e41299.

Prolactin receptor antagonism in mouse anterior pituitary: effects
on cell turnover and prolactin receptor expression
Ferraris J, Boutillon F, Bernadet M, Seilicovich A, Goffin V, Pisera D.. Am J Physiol Endocrinol
Metab. 2012; 302(3):E356-64.

N-terminal Prolactin-derived fragments, vasoinhibins, are proapoptoptic and antiproliferative in the anterior pituitary.
Ferraris J, Radl D B, Zárate S, Jaita G, Eijo G, Zaldivar V, Clapp C, Seilicovich A, Pisera D. PlosOne 2011; 6(7):e21806.

Inhibition of NF-kB sensitises anterior pituitary cells to TNF-a- and LPS-induced apoptosis.
Eijo G, Zárate S, Jaita G, Ferraris J, Magri ML, Zaldivar V, Radl D, Boti V, Pisera D, Seilicovich A. J Neuroendocrinol.
2011; 23(8):651-9.

Dopamine-induced apoptosis of lactotropes is mediated by the short isoform
of D2 receptor. Radl D, Ferraris J, Boti V, Seilicovich A, Sarkar DK, Pisera D.
PlosOne 2011; 6(3):e18097.

Estradiol increases the expression of TNF-a and TNF receptor 1 in lactotropes.
Zaldivar V, Magri ML, Zárate S, Jaita G, Eijo G, Radl D, Ferraris J, Pisera D, Seilicovich A. Neuroendocrinology. 2011; 93(2):106-13.

Gonadal steroids modulate Fas-induced apoptosis of lactotropes and somatotropes.
Jaita G, Zárate S, Ferrari L, Radl D, Ferraris J, Eijo G, Zaldivar V, Pisera D, Seilicovich A. Endocrine. 2011; 39(1): 21-7.

Estrogen receptors and signaling pathways in lactotropes and somatotropes
Zárate S, Seilicovich A. Neuroendocrinology. 2010; 92(4): 215-23.
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